A high-speed two-axis scanner, Vector from 3i (Intelligent Imaging Innovations; Denver, CO), accepts input from a variety of laser sources from UV to visible to near IR.

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VisEn Medical Inc. (Bedford, MA) announced the commercial launch of its new OsteoSense 800 imaging agent for targeting areas of bone turnover and microcalcification in vivo.

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OD-469L High Output Blue LEDs from Opto Diode (Newbury Park, CA) feature a narrow beam angle and are intended for fluorescence in medical, scientific testing instruments, and forensic applications.

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CAMBRIDGE, MA, USA--Scientists at the Massachusetts Institute of Technology (MIT) say they have demonstrated the ability to reversibly halt brain activity in specific neurons using different colors of light. The new tools they developed for this purpose portend new treatments for chronic pain, epilepsy, brain injury, and Parkinson's disease.

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DECEMBER 15, 2009--Andor Technology plc (Andor) announced the support for all Andor imaging EMCCD cameras within JPK Instruments AG's (JPK) products for nano-biotechnology.

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DECEMBER 15, 2009--There is a universal desire among top-end life science researchers to observe tissues and cells more clearly. Optical microscopes are essential for this purpose. However, if multiple objects such as protein molecules cluster at distances of less than 200nm apart, conventional optical microscopes cannot identify them as single objects.

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DECEMBER 16, 2009--Cambridge Research & Instrumentation Inc. (CRi; Woburn, MA) announced the results of a study demonstrating for the first time the capability to detect and automatically measure key activity indicators of cancer cell signal transduction pathways in intact tissue.

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JANUARY 5, 2010--"The market for OCT systems is entering a new phase as it moves beyond ophthalmology and is applied to new medical specialties," reports a new market research study by Strategies Unlimited (Mountain View, CA). The report says that despite the dismal 2009 economy, sales of optical coherence tomography (OCT) systems grew to $315 million, and a compound annual growth rate of 20% is expected through 2014.

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Where do presidential candidates Barack Obama (D-IL) and John McCain (R-AZ) stand on science and technology issues? Getting the answer to that question isn't easy.

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WASHINGTON, DC, USA--A comprehensive and independent education on the latest techniques in fluorescence imaging: That's the goal of a new website, developed by Carl Zeiss in collaboration with renowned imaging expert and online teaching pioneer Mike Davidson of Florida State University. The site includes a review of light sources and explains techniques such as the one used to create this image: a 3D reconstruction of optical sections of mouse skin generated by structured illumination.

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BOSTON, MA, USA -- For the first time researchers are getting a detailed look at the interior of human coronary arteries, using optical frequency-domain imaging (OFDI), a technique developed at Massachusetts General Hospital. OFDI gives three-dimensional, microscopic views of significant segments of coronary arteries, visualizing areas of inflammation and plaque deposits. While optical coherence tomography (OCT) examines tissues one point at a time, OFDI can look at >1000 points simultaneously.

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LONDON, ENGLAND -- The UK's OMICRON project, which is working to develop an optical coherence tomography (OCT) based in-vivo imaging probe operating at the new, untried wavelength of 1 micron, has produced its first super high resolution sub-surface tissue images. The images (scale bar is 1 micron) depict skin on the knuckle of a human finger and clearly show capillaries (indicated by the arrow). To date, most imaging of skin tissue has been done at the longer wavelength of 1.3 microns.

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HEIDELBERG, GERMANY -- Scientists at the European Molecular Biology Laboratory (EMBL) grow cells as cysts in three-dimensional matrices to create more life-like conditions. EMBL's newly designed Single Plane Illumination Microscope enabled Emmanuel Reynaud to image these human kidney cysts. The cysts -- sacs with a liquid filled lumen surrounded by a single layer of cells -- are magnified 400 times. Images of 3D cultures show cell behavior, shapes, and arrangements as they occur in the body.

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NEW YORK, NY -- The Popular Vote winner in Nikon's 2008 Small World Photomicrography Competition -- that is, the image most favored by the public -- features a chick embryo. The stunning photo was captured by Tomas Pais de Azevedo of Lisbon, Portugal, a biology student currently enrolled in a master's course on evolutionary and developmental biology.

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HEIDELBERG, GERMANY -- With a newly developed Digital Scanned Laser Light Sheet Microscope, scientists at the European Molecular Biology Laboratory (EMBL) were able to track, for the first time, all cells for the first 24 hours in the life of a vertebrate animal. The data was reconstructed into a 3-D, digital representation. Here you can see the digital embryo (left halves, colors encode movement directions of cells) and microscopy data (right halves) at different points in time.

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HEIDELBERG, GERMANY -- An international team of scientists has succeeded in optically detecting individual action potentials in the brains of living animals. They introduced fluorescent indicator proteins into the brain cells of mice via viral gene vectors: Illumination of the proteins indicates when and which neurons are communicating. The method enables observation of brain activity over time and early onset of dysfunction in Alzheimer's and Parkinson's diseases.

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CAMBRIDGE, MASS, USA -- MIT researchers have shown in great detail how the malaria parasite attacks red blood cells. They were aided by two advanced microscopy techniques: Diffraction phase microscopy, and tomographic phase microscopy -- developed at MIT -- which assembles about 100 2-D images to create a 3D view.

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Boulder, CO, USA -- As part of a new six-week paid externship program launched by the Colorado BioScience Association (CBSA), Bear Creek High School biology teacher Tamra Miaja spent part of her summer at Array BioPharma in Boulder. Miaja, the first teacher to take part in the program, worked in Array's molecular biology and protein chemistry group, crystallizing proteins and determining their structure. She used spectrophotometers among other tools in her work.

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Champaign, IL, USA -- The layout of a new high-performance, hemispherical camera uses stretchable optoelectronics to mimic operation of the human eye. Researchers at the University of Illinois and Northwestern University used an array of single-crystalline silicon detectors and electronics, configured in an interconnected mesh, to create the device. The work foreshadows advanced cameras and artificial retinas like those in the movie "Terminator."

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Calgary, Alberta, Canada -- The University of Calgary's Sun Center of Excellence for Visual Genomics is home to the CAVEman project. The project aims to create visual maps of information about diseases that have a genetic component, such as cancer, diabetes, and Alzheimer's. The CAVE, an immersive virtual reality environment, will let researchers "see" specific disease processes and the effects of interventions.

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DECEMBER 9, 2008--Biotechnology company Transgenomic (Omaha, NE) has gained an exclusive license to patents covering a method for mitochondrial DNA (mtDNA) damage detection. The patents form the basis for diagnostic tests for heart disease, diabetes, cancer, and other diseases. The approach, invented in Dr. Ben Van Houten's University of Texas lab, measures oxidative damage within the organelles that supply energy to cells.

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DECEMBER 8, 2008--Proteomics probe developer AnaSpec (San Jose, CA) has signed a non-exclusive distribution agreement with Yope Biotechnology Co. Ltd. to distribute AnaSpec's catalog and custom protein identification products throughout China.

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DECEMBER 8, 2008--Scientists at Intel Labs (Santa Clara, CA) say they have made an important advance in silicon photonics, having achieved world-record performance using a silicon-based avalanche photodetector (APD). The work could lower costs and improve performance as compared to commercially available optical devices. This APD device used silicon and CMOS processing to achieve a "gain-bandwidth product" of 340 GHz.

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DECEMBER 8, 2008--Researchers at Emory University and the Georgia Institute of Technology have found a way around the traditional limitations of quantum dots, which hold promise for early detection and treatment of cancer. By exploiting a property of semiconductors called "lattice strain," they have addressed challenges with the nanoparticles' size and potential toxicity. Strain-tuned 4 x 6nm quantum dots can emit light at wavelengths in the NIR range, enabling viewing through body's tissue.

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DECEMBER 5, 2008--SpectraScience Inc. (San Diego, CA) has been awarded a European patent for its optical biopsy system, which targets tissue diagnosis and reliable cancer screening. The patent supports SpectraScience's technology for use of non-invasive, low-level lasers to diagnose pre-malignant tissue, malignant tumors and lesions, for early cancer detection and therapy.

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DECEMBER 5, 2008--The National Science Foundation (NSF) has awarded a $480K grant to the startup Newton Photonics Inc. (Newton, MA) to create a blood glucose meter based on optical coherence tomography (OCT). Eventually targeted for in-home use by those with diabetes, the noninvasive sensor, capable of continuous blood sugar monitoring, is expected to enter clinical trials within 18 months.

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DECEMBER 4, 2008--Imaging3, Inc. (Chicago, IL), medical device manufacturer, distributor and service provider, released its newest imaging software at this week's Radiological Society of North America (RSNA) conference. The updated 3D Orthographic Perspective Interface Software complements Imaging3's patented new medical imager, the Dominion Volumetric Imaging Scanner (DViS), which produces 3D medical diagnostic views of virtually any human body part dynamically.

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DECEMBER 2, 2008--Having added four new fluoroscopy systems to its lineup, Carl Zeiss MicroImaging (Jena, Germany) now claims the largest family of optical sectioning microscopes available. The new systems are Cell Observer SD, a spinning disk microscope system for high-speed confocal imaging; LSM 700, a high-performance personal confocal; LSM 7 MP, a flexible multiphoton system; and Laser TIRF 3, a reproducible, flexible total internal reflection microscope.

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DECEMBER 3, 2008--Canon U.S.A. is celebrating 10 years in digital radiography (DR) at this week's 2008 Radiological Society of North America Annual Meeting by showcasing its line of DR products. Canon is also previewing a future medical fluoroscopic device: a lightweight, portable flat-panel DR system that supports both standard static X-ray image capture and fluoroscence microscopy. The design aims to enable radiographers to observe organ operation and dynamics.

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DECEMBER 2, 2008--Each year the Radiologic Society of North America honors one scientist with its "Outstanding Researcher of The Year" award. This year that honoree is Ralph Weissleder, MD, PhD of Harvard Medical School and Massachusetts General Hospital, who co-founded VisEn Medical Inc. (Bedford, MA). Weissleder has made significant contributions to molecular imaging, especially for application to cancer, atherosclerosis and inflammatory diseases.

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DECEMBER 2, 2008--Researchers in Paris, France confirm, for the first time, that long-distance excursions of enzyme on DNA are possible. To prove that EcoRV enzymes can not only slide along DNA strands, but jump between them as well, the team combined a high frame-rate digital camera capable of single photon sensitivity together with a total internal reflection microscope (TIRFM). The team hopes the discovery will enable genetic disease research.

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DECEMBER 1, 2008--The Council for Advancement and Support of Education and The Carnegie Foundation have given Wei R. Chen, professor of biomedical engineering at the U of Central Oklahoma (Edmond, OK) one of four U.S. Professors of the Year awards. Chen led the establishment of Central Oklahoma's undergrad degree program in biomedical engineering. He guides students in using laser immunotherapy as part of his lab's cancer therapy research.

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DECEMBER 1, 2008--At its new Nitto Denko Asia Technical Centre (NAT) in Singapore, Nitto Denko Corp. (Tokyo, Japan) with partner with Nanyang Technological University (NTU) on research that combines the company's expertise in polymer waveguides with NTU's photonics knowledge. "The optical waveguides that we are researching can be used in biosensor for early detection of diseases such as SARS [severe acute respiratory syndrome] or heart disease," says NTU.

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NOVEMBER 28, 2008 -- An international consortium of researchers has begun to sequence the full set of chromosomes of the domesticated turkey using the Roche GS-FLX sequencing platform. The assembled genome will be compared with the chicken DNA sequence to examine similarities and differences in organization. The sequence and genomic resources developed from the project are expected to enable breeding for specific production traits.

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NOVEMBER 26, 2008--Light Sciences Oncology (Bellevue, WA) has completed enrollment in a global Phase 3 clinical trial of its Light Infusion Therapy ("Litx") as light-activated treatment for unresectable hepatocellular carcinoma (HCC), also known as hepatoma or primary liver cancer. LSO hopes to enter a New Drug Application to the U.S. FDA, EMEA, and other authorities in 2009. The single-use, disposable Litx device uses light-emitting diodes (LEDs) to activate a water-soluble drug.

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NOVEMBER 25, 2008--Imaging Diagnostic Systems (Fort Lauderdale, FL), developer of laser optical breast imaging systems, has received its 21st US patent. The patent covers a key technology for time-resolved optical imaging that improves the quality of data and decreases the time required to capture it. The concept is the basis for a new imaging device designed to augment traditional mammography for breast cancer detection and management.

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NOVEMBER 24, 2008--LCA-Vision Inc. (Cincinnati, OH), provider of LasikPlus laser eye surgery services, has appointed Michael J. Celebrezze as CFO. Meanwhile, the company's founders and former executives have filed with the U.S. Securities and Exchange Commission saying they are considering actions to protect their investment and help turn around the company's flagging performance.

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NOVEMBER 21, 2008 -- Sensys Medical (Chandler, AZ), developer of non-invasive blood glucose monitoring technology, is relocating its world headquarters to the UK according to UK Trade and Investment. Sensys's device is able to read blood glucose levels an unlimited number of times a day via near-infrared spectrometry, and is expected to greatly enhance management of blood sugar levels for diabetes patients.

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NOVEMBER 21, 2008 -- Raydiance (Petaluma, CA), which calls itself "the world's first practical source of ultrafast light," has secured $20 million to scale infrastructure, evolve its technology and address larger markets. Simultaneously, the company released Discovery 2.0, an upgrade to its ultrashort pulse (USP) laser platform, which promises to build upon customers applications in ophthalmology, dermatology, gene transfection, and surgery.

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NOVEMBER 20, 2008 -- MedX Health Corp. (Mississauga, ON, Canada), developer and manufacturer of low level laser therapy (LLLT) and light medical devices for tissue repair and pain relief, has entered into a co-marketing, development and distribution agreement with Naimco/Rich-Mar, provider of advanced ultrasound, electrotherapy and light therapy modalities.

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NOVEMBER 20, 2008 -- Researchers at Children's Hospital of Orange County (Orange, CA) and Vanderbilt University (Nashville, TN) report that a handheld device may enhance the differential diagnosis of non-melanoma skin cancers, inflamed scar tissue and normal skin in vivo. The study, published in Lasers in Surgery and Medicine, discussed the advantages of using Raman microspectroscopy to examine and classify pathologic skin cells.

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NOVEMBER 19, 2008 -- Eleme Medical, developer of aesthetic body-sculpting technology, has launched its SmoothLipo in the US. The laser device promises effective body reshaping without major surgery, plus dermatology benefits: consistent smoothing and skin tightening. Minimally invasive laser-assisted lipolysis/"smart lipo" contours the body by dissolving local fat deposits; the treatment is recommended for areas where firm, smooth-looking skin is desired.

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NOVEMBER 19, 2008 -- Scientists at the University of Pittsburgh have developed a fast, easy method for determining mercury levels in fish and dental samples -- both objects of public concern about mercury poisoning. The technique involves a fluorescent substance that glows when it contacts oxidized mercury; intensity indicates level. The method differs from similar indicators in that it withstands the oxidation process samples must undergo.

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NOVEMBER 18, 2008 -- PLC Systems (Franklin, MA), developer of the CO2 Heart Laser System and other medical devices for treatment of heart disease and vascular conditions, says that its common stock is now trading on the over the counter bulletin board market under the symbol "PLCSF," following receipt of approval by the Financial Industry Regulatory Authority (FINRA).

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NOVEMBER 18, 2008 -- Nikon Instruments (Melville, NY) and Thorlabs (Newton, NJ) have collaborated to bring optical coherence tomography (OCT) to Nikon's FN1 "PhysioStation" upright focusing nosepiece microscope system for neurophysiology and in vivo, small-animal studies. Designed for neuroscience and electrophysiology applications, the new OCT system enables an imaging depth of 2-3 mm in biological tissue with a larger field of view than in conventional microscopy.

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NOVEMBER 16, 2008 -- Researchers at Yeshiva University's Albert Einstein College of Medicine (Bronx, NY) have described for the first time a method of viewing individual breast cancer cells for several days at a time. The study details how cancer cells invade surrounding tissue and reach blood vessels -- steps that lead to metastasis. Prior methods allowed cells to be viewed clearly for several hours at most. Using intravital imaging, the researchers used a "photoswitch" to mark cancer cells.

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NOVEMBER 17, 2008 -- The U.S. Food and Drug Administration (FDA) has cleared LED Technologies' (Elizabeth, CO) Deep Penetrating Light (DPL) Therapy System for home use. The system enables relaxation of muscles and relief of muscle spasms, temporary relief of minor muscle and joint aches, pains and stiffness; temporary relief of minor pain and stiffness associated with arthritis; and temporarily increases local blood circulation.

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NOVEMBER 13, 2008 -- Haemonetics (Braintree, MA), a global provider of blood management technologies for hospitals and blood and plasma collection agencies, has licensed from the National Institute of Standards and Technology (NIST, Bethesda, MD) a patented optical tweezers technique. The technique enables detection and measurement of femtomolar concentrations of biological substances -- a single virus on a surface, for instance, or one antigen particle per quadrillion water molecules.

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NOVEMBER 13, 2008 -- Texas Instruments has announced a portfolio of more than 15 dedicated embedded processors designed to speed optical coherence tomography (OCT) among other medical imaging modalities. This, says TI, will improve imaging accuracy, and enable equipment manufacturers to develop new modalities or make current systems smaller and more portable. The processors are extensible so researchers can easily upload new algorithms to field-deployed machines.

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NOVEMBER 12, 2008 -- Reliant Technologies and Palomar Medical have formed the Fractional Technology Open Patent Program to license key intellectual property in fractional laser and light-based technology owned or controlled by Reliant, Palomar and Massachusetts General Hospital. The technologies are clinically proven for dermatology and skin aesthetics applications. The partners say the program enables developers to avoid infringing a large number of patents.

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NOVEMBER 12, 2008 -- The European Patent Office has granted a patent to Nomir Medical (Waltham, MA) that protects the company's core Noveon technology. Noveon is a light-based system that uses a near-infrared (NIR) photo-inactivation effect to kill bacteria and fungi causing infections, while preserving healthy tissue -- for instance in human fingers, toes, gums, ears, and noses. The patent coverage provides for use of two proprietary near-IR wavelengths.

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NOVEMBER 11, 2008 -- Ellex Medical Lasers (Adelaide, Australia) announced results of a six-month clinical study for retina regeneration during this week's American Academy of Ophthalmology meeting. The results show that Ellex's 2RT laser is safe and effective in treatment of macular edema secondary to diabetic retinopathy. "For the first time, we can obtain all the therapeutic benefits seen with earlier laser treatments, but without the collateral damage," said study leader Dr. John Marshall.

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NOVEMBER 11, 2008 -- Canon USA (Lake Success, NY) is showcasing its "complete line of total digital imaging and workflow management solutions for eyecare professionals" this week at this week's American Academy of Ophthalmology annual meeting. In particular, Canon is demonstrating synergy between its own retinal cameras and optical coherence tomography (OCT) products from Optopol Technology SA (Zawiercie, Poland) -- which Canon is now distributing in the US.

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NOVEMBER 10, 2008 -- Reliant Technologies (Mountain View, CA) presented study results comparing fractional laser technology to pseudo fractional lasers during last week's American Society for Dermatologic Surgery meeting. The data demonstrates that "true" fractional systems provide superior safety and efficacy compared to those that use altered ablative technology. The lasers are used for for skin resurfacing and rejuvenation on the face, eyelids, the neck, and hands, as well as on scars.

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NOVEMBER 10, 2008 -- Carl Zeiss Meditec (Dublin, CA) is announcing new and updated technology at this week's American Academy of Ophthalmology (AAO) meeting. The new systems include diagnostic and surgical applications covering the entire spectrum of patient care and supporting cataract/refractive, retina and glaucoma treatment. Technologies include coaxial illumination, photocoagulation, optical coherence tomography, femtosecond lasers, and intraocular lenses (IOLs).

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NOVEMBER 9, 2008 -- Linda Smith, founder of Peloton Diagnostics Corp. (Wellesley, MA) is one of five women entrepenuers selected to participate in the inauguration of Ernst & Young Strategic Growth Forum 2008, (November 12-16, Palm Springs, CA). Peloton Diagnostics supplies medical diagnostics tools based on optical imaging technologies that promise to advance preventative and personalized medicine.

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NOVEMBER 9, 2008 -- Lumenis Ltd. (Yokneam, Israel) has introduced four new ophthalmic lasers and delivery devices at the American Academy of Ophthalmology (AAO) annual meeting, which began Friday. The company is demonstrating two units that combine technologies and applications for flexibility and performance; a powerful dual-port photocoagulator; and a family of endo photocoagulation laser probes for retinal applications.

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NOVEMBER 6, 2008 -- Ahura Scientific (Wilmington, MA) today announced a corporate milestone: shipment of 2000 chemical identification devices. Ahura says the achievement follows increasing demand for its award-winning Raman spectroscopy-based FirstDefender and TruScan instruments, and its newest product, TruDefender FT, based on Fourier-Transform Infrared (FTIR) spectroscopy. Ahura shipped its first product in May 2005; pharmaceuticals giant AstraZeneca PLC purchased the 2000th unit.

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NOVEMBER 7, 2008 -- Emergent Group Inc. (Sun Valley, CA), provider of mobile medical and cosmetic lasers and surgical equipment, has been approved for listing on the NYSE Alternext US, formerly the American Stock Exchange. The company anticipates trading on the exchange to begin the week of November 10 under the ticker symbol "LZR".

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NOVEMBER 6, 2008 -- Syneron Medical Ltd. (Yokneam, Israel), developer of medical aesthetic devices, has agreed to acquire laser technology firm Inlight Corp. (San Diego, CA). As part of the agreement, Inlight president and co-founder Shlomo Assa, who holds multiple U.S. patents for laser-based technology, will join the Syneron management team. Syneron will leverage Inlight technology for new laser skin care products, to launch starting in 2009.

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NOVEMBER 5, 2008 -- Ellex Medical Lasers (Adelaide, Australia) says two wavelengths and high power not previously available in photocoagulators -- 1.5 watts of 561nm yellow and 1 watt of 670nm red -- permits the full treatment range of three-wavelength photocoagulators, displacing green lasers for eye surgery. During the American Academy of Ophthalmology conference starting this weekend, the company will preview new technology based on this concept.

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NOVEMBER 5, 2008 -- Biomedical and analytical instrumentation has long had need for long-wavelength excitation Raman spectroscopy for lab, hospital bedside, and portable field work. Now BaySpec Inc. (Fremont, CA) and Andor Technology (Belfast, Northern Ireland) say their collaboration has yielded a solution: new technology with 1064nm capability that enables up to three times the collection efficiency of standard Czerny-Turner spectrographs.

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NOVEMBER 4, 2008 -- Carl Zeiss (Jena, Germany) and the Foundation for Innovative New Diagnostics (Geneva, Switzerland), have partnered to develop a new fluorescence microscope that promises fast, reliable, and affordable detection of tuberculosis (TB). Zeiss will supply the LED-based device at low cost to the public health sector of the countries worst affected by the contagious, fatal disease.

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NOVEMBER 3, 2008 -- The Optical Society's (OSA) Interactive Science Publishing (ISP) initiative provides software for interactively viewing underlying source data and enabling researchers, scientists and engineers to objectively compare the performance of different technologies for medical imaging and other applications.

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OCTOBER 31, 2008 -- Accumetrics Inc. (San Diego, CA) has named Timothy I. Still as its new Chief Executive Officer. Mr. Still has served as Accumetrics' President and COO since earlier this year. His commercialization expertise and diagnostic market experience will help the company bring to market its VerifyNow system, which aims to help doctors assess response to antiplatet therapy for patients at risk for cardiovascular disease.

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OCTOBER 31, 2008 -- Spartan Bioscience Inc. (Ottawa, Ontario), developer of DNA analyzers for on-demand applications, and NorDiag ASA (Bergen, Norway), developer of automated nucleic acid sample preparation instruments and reagents, say they will partner to develop an end-to-end DNA preparation and analysis system. Their goal is a fast, affordable, and user-friendly genetic sequencing system for release in 2009.

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OCTOBER 30, 2008 -- MDS Analytical Technologies (Sunnyvale, CA), announced today that the Abraxis Melamine Detection Kit has been validated for use with its SpectraMax absorbance microplate readers. The solution promises a cost-effective, high-throughput, quality-assurance solution to detect melamine contamination in food products such as milk, infant formula, pet food, and confectionery.

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OCTOBER 30, 2008 -- Clemson University (Clemson, SC) researchers have received a grant to pursue a new cancer-detection method that combines light and MRI (magnetic resonance imaging). They have implanted magnetic elements into carbon quantum dots, enabling the nanostructures to serve as a contrast agent for both light- and magnetic-imaging techniques for early cancer diagnosis. "It may be a more efficient, pinpointed way of detecting where the cancers are," they say.

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OCTOBER 29, 2008 -- Standard Security Life Insurance has begun offering a one-time benefit for laser vision correction procedures to members covered by sponsoring health plans. "To our knowledge, this is the first offering of this kind for laser vision correction services and we are delighted to be named a network provider," says LCA-Vision (Cincinnati, OH), known for its Lasik services. LCA predicts the benefit will motivate interested members concerned about costs.

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OCTOBER 28, 2008 -- High-intensity visible light from light emitting diodes (LEDs), applied daily for several weeks to facial wrinkles, resulted in "rejuvenated skin, reduced wrinkle levels, juvenile complexion and lasting resilience," according to researchers in Germany. Their study indicates that the LED therapy may be an alternative to Botox, cosmetic surgery, and similar skin rejuvenation treatments. And, the researchers say, their work could be developed for "deep body rejuvenation."

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OCTOBER 27, 2008 -- The Molecular Imaging and Contrast Agent Database (MICAD) has added a number of new probes, including two for optical molecular imaging that target a prostate-specific membrane antigen and lysosomes, respectively. These and 544 other agents for various modalities -- including optical -- are available through MICAD, a key component of the National Institutes of Health (NIH) Roadmap.

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OCTOBER 27, 2008 -- PixelOptics (Roanoke, VA) has closed on a $30 million Series C financing round. The company will use the funds to develop a complete offering of composite lenses for eye glasses that incorporate its electro-active technology. PixelOptics "is successfully applying its know-how of composite optics, electronics and chemistry to the development of a mainstream product that we expect will benefit millions of people worldwide," says Longitude Capital, which led the funding round.

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OCTOBER 24, 2008 -- Andrea Armani of the University of Southern California has adapted an optical microcavity resonance technique for rapidly detecting even individual unlabelled target molecules. Her technique addresses the issue that even very small numbers of deadly infectious agents or allergenic pollen molecules can cause major problems for humans -- but detecting trace amounts quickly enough to do any good has been a challenge.

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OCTOBER 24, 2008 -- Trinean NV (Gentbrugge, Belgium), develops and markets what it calls "the first nanoliter spectrophotometer," has closed on 3.5 million Euro of financing. The funds will allow Trinean to start production, bring its products to market for nucleic acid concentration measurement, and develop applications such as ADME testing and protein quantitation.

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OCTOBER 22, 2008 -- An in vivo multi-photon laser scanning microscope has enabled observation of a phenomenon never seen before. The system enabled a team of scientists at Duke University (Durham, NC) to see inside the brain of a baby ferret as it opened its eyes for the first time and learned to interpret moving images. The approach, which highlights changes within individual neurons as an indication of electrical activity, may help scientists understand neurological and psychiatric disorders.

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OCTOBER 23, 2008 -- InfraScan (Philadelphia, PA) says it has obtained the CE mark, European marketing clearance, for its Infrascanner handheld brain hematoma detector. The device detects brain hematoma presence and location using differential NIR light absorption. It is reportedly the first handheld device of its kind designed to assist first responders and emergency room personnel identify such brain injuries, allowing expedient assessment of patients and facilitating treatment.

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OCTOBER 22, 2008 -- Tomophase Corp. (Burlington, MA) says it will display the first in-vivo cross-sectional images of implanted lung stents using its optical coherence tomography (OCT) technology next week. "Much of the structure in the airways beneath the epithelial layer is essentially invisible to clinicians. Providing real-time access to this information could provide major benefits" for both diagnostics and therapy, the company says.

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OCTOBER 20, 2008 -- Laser hair removal therapies seem to be safer and remove unwanted hair more effectively when used separately than when used in combination, according to a report in the October issue of Archives of Dermatology.

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OCTOBER 21, 2008 -- David Huang, holder of the Charles C. Manger III Chair in Corneal Laser Surgery at the Keck School of Medicine of the University of Southern California, is the principal investigator of a new $8.9 million grant from the National Institutes of Health to study glaucoma, a leading cause of blindness. The study will seek to advance optical coherence tomography (OCT) for this application, to enable early diagnosis before vision loss is irreversible.

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OCTOBER 21, 2008 -- Photodynamic therapy (PDT) appears to produce changes -- consistent with increased collagen production and improved appearance -- at the molecular level in aging skin, according to a report in the October issue of Archives of Dermatology. The report is based on a study of people with sun-damaged skin.

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OCTOBER 20, 2008 -- Michael Kulick, MD (San Francisco, CA), has developed a data-oriented 3D imaging validation method for quantitatively measuring cellulite. Dr. Kulick is a key investigator involved in an IRB-approved, multi-center, clinical study to investigate the efficacy of Eleme Medical's (Merrimack, NH) SmoothShapes system, which promises cellulite improvement through its Photomology technology.

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OCTOBER 17, 2008 -- Actar AB, a start-up company that is part of the Karolinska Institutet innovations system (Stockholm, Sweden), has begun providing label-free drug screening services, made possible by its recent purchase of the Corning Epic System. Actar is the only company to provide such drug discovery services to academic researchers in Scandinavia and Europe on a fee-for-service basis.

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OCTOBER 17, 2008 -- Researchers at Baylor University (Waco, TX) have applied a statistical method to spectroscopy-based chemical measurements to determine the post-mortem interval of bones -- which is the time period since a person has died. The method is significantly faster than other forensics methods, and is effective for distinguishing short time intervals.

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OCTOBER 15, 2008 -- Kensey Nash (Exton, PA) says it has completed development of an optical coherence reflectometry (OCR)-based system designed to safely cross and recanalize chronic total occlusions (CTOs) in the coronary and peripheral arteries. It promises physicians a superior visual display of data transmitted by a guidewire in the vessel. This is the first milestone under Kensey Nash's R&D agreement with Spectranetics, which recently purchased rights to the product.

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OCTOBER 16, 2008 -- T-Ray Science, Inc., (Vancouver, BC, Canada) has filed for provisional patent protection with the U.S. Patent and Trade Mark Office on a dual-mode terahertz spectroscopy and imaging system, and a critical component of that system. The technology lays a foundation for development of portable biomedical scanners devices useful in doctor's offices skin-care clinics, etc. T-Ray reportedly holds licenses to the only two dual-mode THz spectroscopy systems in the world.

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OCTOBER 15, 2008 -- 3DIcon Corp. (Tulsa, OK) says it has completed a working prototype of its proprietary three-dimensional display system, CSpace. CSpace, it says, instantaneously creates one-color volumetric 3D images that can be viewed from any angle without viewing aids. The company hopes the technology will enable life-saving applications in medical imaging, including disease diagnosis.

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OCTOBER 15, 2008 -- A consortium led by Fianium (Eugene, OR) is working on advanced white-light (supercontinuum) fiber lasers for biomedical imaging applications. The "WhiteLase" project aims to deliver UV-content supercontinuum sources (to below 300nm) and ultra-bright visible supercontinuum sources, and evaluate them in fluorescence imaging applications. The new lasers promise spectral power densities an order of magnitude higher than those currently available.

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OCTOBER 14, 2008 -- Scientists at the Institute of Photonics, University of Strathclyde are developing novel solid-state lasers incorporating CVD diamond manufactured by Element Six Ltd (Ascot, UK). The expected result is minature, power-efficient lasers able to operate at now-unavailable wavelengths including "applications-rich, but currently source-poor, yellow-orange." Diamond Raman lasers could enable applications in medical imaging, ophthalmology, cancer therapy, and multispectral imaging.

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OCTOBER 13, 2008 -- A new product development and distribution agreement between Urodynamix Technologies (Vancouver, B.C., Canada) and Timm Medical Technologies gives Timm exclusive worldwide distribution rights for application of Urodynamix's near infrared spectroscopy (NIRS) technology for the measurement of penile blood flow in erectile dysfunction (ED) patients. Subject to regulatory approvals, Timm expects to begin marketing NIRS ED products in the US in 2009.

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OCTOBER 13, 2008 -- The independent research center IMEC (Leuven, Belgium) says its laboratory at the Ghent University, INTEC, has made the first functional optical links embedded in a flexible substrate. The technique enables production of stretchable foils that sense pressure changes -- which could be used as a synthetic skin. Applications include long-term monitoring of respiration and cardiac activity, and detection of pressure points under bed-ridden patients.

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OCTOBER 13, 2008 -- A team of researchers reports that optical coherence tomography (OCT) provides superior contrast and resolution for imaging the components of coronary artery plaque versus other methods. Their findings are being presented this week at the Transcatheter Cardiovascular Therapeutics scientific symposium. "OCT may answer longstanding questions about the relationship between vulnerable plaque and the risk of heart attack," said lead investigator So-Yeon Choi, M.D., Ph.D.

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OCTOBER 10, 2008 -- Reliant Technologies (Mountain View, CA), the pioneer of fractional resurfacing and market leader of aesthetic laser skin treatments, says it has received FDA 510(k) clearance for three new Fraxel re:pair laser handpieces. The handpieces expand the capabilities of the Fraxel re:pair laser system, providing physicians with "a complete skin resurfacing and surgical treatment option."

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OCTOBER 10, 2008 -- Two developers of laser-based biomedical equipment have announced their first product sales: Imaging Diagnostic Systems, developer of laser optical breast cancer imaging systems, has sold its CT Laser Mammography System (CTLM) system to the Hadassah University Medical Center in Israel. And CustomVis (Perth, Australia), which specializes in solid-state laser systems for eye surgery, says it has made the first sale of its flagship product, the Pulzar Z1, in Peru.

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OCTOBER 9, 2008 -- During this week's annual meeting of the American College of Gastroenterology, Mayo Clinic researchers reported that a virtual biopsy probe, sensitive enough to determine whether a single cell in the colon shows signs of cancer, was 90% accurate in identifying harmless polyps in patients. They say that with further development, the system, known as probe-based confocal laser endomicroscopy (pCLE), will be nearly 100% accurate in detecting colon cancer.

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OCTOBER 8, 2008 -- New research indicates the benefits of single-cell profiling for understanding some complex cancers. "By measuring how signaling proteins respond to certain stimuli at diagnosis and which are modified by resistant cancers, we are essentially monitoring key highways that cancers use to drive their own growth," explains Dr. Garry Nolan, one of the research leaders. Advances in flow cytometry enabled the discovery, which could lead to very early cancer diagnosis.

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OCTOBER 7, 2008 -- The US Food and Drug Administration (FDA) has cleared MedX Health's (Mississauga, Canada) Oralase Portable Laser for marketing. Oralase, a low level laser therapy (LLLT) device, is designed to alleviate pain and accelerate tissue repair following dentistry procedures. The device also promises to relieve pain and accelerate healing in cosmetic surgery and skin treatments.

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OCTOBER 7, 2008 -- An international group of companies and individuals has formed a joint venture it is calling imaeon. The new company, operating from India and Belgium, will provide analysis of medical images -- derived from optical coherence tomography (OCT) and other technologies -- for clinical research projects in the pharmaceutical, biomedical and medical device industries.

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OCTOBER 6, 2008 -- Researchers at Imperial College London say they have discovered the first new method in more than 20 years for identifying proteins. Their technique, coherent two-dimensional infrared spectroscopy (2DIR), maps energy flow inside a protein. The scientists hope to develop a tool based on the technology to determine proteins and their concentrations within a human cell. Proteins are involved in every process in human cells, including cancer growth.

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OCTOBER 3, 2008 -- Yokogawa Electric (Tokyo, Japan) says high-performance microscope giant Carl Zeiss Group, will sell the Yokogawa CSU-X1 confocal scanner unit in all markets outside Japan. Zeiss will incorporate the CSU-X1 into its Cell Observer SD confocal microscope system; sales will begin next month and will target living cell research for medicine, molecular biology, and related applications.

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OCTOBER 3, 2008 -- Researchers at NorthShore University HealthSystem and Northwestern University have found that fiber optic technology can effectively measure blood levels in the colonic lining in humans. This has potential for analyzing colon cancer risk. The study used fiber optics to map microvascular blood content in patients during colonoscopy. The results provide the first evidence that the condition is detectable in humans, and that it indicates tumor development.

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